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anti erk  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc anti erk
    Anti Erk, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 137 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti erk/product/Cell Signaling Technology Inc
    Average 95 stars, based on 137 article reviews
    anti erk - by Bioz Stars, 2026-03
    95/100 stars

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    primary antibodies trka  (Cell Signaling Technology Inc)
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    Dose-response curves for pERK (middle) and pAKT (right) activation measured via phosphoflow for different backbone classes of all designs (colored) (A) Large designs (B) DHR04-based (C) 6-helical bundles (D) 6-helical short connector bundles (E) direct fusions and (F) direct long fusions. Error bars represent SD from three independent biological repeats. (G) Activation strength for the individual designs correlate <t>for</t> <t>ERK</t> and AKT phosphorylation. (H) Designs Nt-231 (top) and Nt-237 (bottom) were tested for specific <t>TrkA</t> pathway activation using a SRE-luciferase reporter gene and treatment with different concentrations of agonists. Designs did not lead to pathway activation of TrkB or TrkC. Error bars represent SEM from five independent biological repeats. (I) Time-course of TrkA receptor endocytosis for various concentrations of Nt-231 (top), Nt-237 (middle) agonists or NGF (bottom) using a BRET assay. Error bars represent SEM from five independent biological repeats.
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    Dose-response curves for pERK (middle) and pAKT (right) activation measured via phosphoflow for different backbone classes of all designs (colored) (A) Large designs (B) DHR04-based (C) 6-helical bundles (D) 6-helical short connector bundles (E) direct fusions and (F) direct long fusions. Error bars represent SD from three independent biological repeats. (G) Activation strength for the individual designs correlate for ERK and AKT phosphorylation. (H) Designs Nt-231 (top) and Nt-237 (bottom) were tested for specific TrkA pathway activation using a SRE-luciferase reporter gene and treatment with different concentrations of agonists. Designs did not lead to pathway activation of TrkB or TrkC. Error bars represent SEM from five independent biological repeats. (I) Time-course of TrkA receptor endocytosis for various concentrations of Nt-231 (top), Nt-237 (middle) agonists or NGF (bottom) using a BRET assay. Error bars represent SEM from five independent biological repeats.

    Journal: bioRxiv

    Article Title: Designed NGF mimetics with reduced nociceptive signatures in neurons

    doi: 10.1101/2025.04.14.648806

    Figure Lengend Snippet: Dose-response curves for pERK (middle) and pAKT (right) activation measured via phosphoflow for different backbone classes of all designs (colored) (A) Large designs (B) DHR04-based (C) 6-helical bundles (D) 6-helical short connector bundles (E) direct fusions and (F) direct long fusions. Error bars represent SD from three independent biological repeats. (G) Activation strength for the individual designs correlate for ERK and AKT phosphorylation. (H) Designs Nt-231 (top) and Nt-237 (bottom) were tested for specific TrkA pathway activation using a SRE-luciferase reporter gene and treatment with different concentrations of agonists. Designs did not lead to pathway activation of TrkB or TrkC. Error bars represent SEM from five independent biological repeats. (I) Time-course of TrkA receptor endocytosis for various concentrations of Nt-231 (top), Nt-237 (middle) agonists or NGF (bottom) using a BRET assay. Error bars represent SEM from five independent biological repeats.

    Article Snippet: After blocking the membrane in 5% milk, 0.1% Tween, 10 mM Tris at pH 7.6, 100 mM NaCl, primary antibodies TrkA (Cell Signaling, Cat. 30697 at 1:1000), ERK (Cell Signaling, Cat. 9107), pERK (Cell Signaling, Cat. 4695), HSC70 (Santa Cruz, Cat. sc-7298; at 1:10.000), and Beta-Actin (Sigma, Cat. A1978 at 1:10,000) were added.

    Techniques: Activation Assay, Phospho-proteomics, Luciferase, Bioluminescence Resonance Energy Transfer